Tramadol HCL compared to other painkillers
Tramadol vs. Codeine
Tramadol and codeine are related drugs, making part of the same class of substances and having similar analgesic effects. However Tramadol HCL delivers a less euphoric, constipating and respiratory depressant effect.
Metanalysis and comparison of Tramadol and codeine indicates that a smaller amount of Tramadol is required to reach the efficacy of codeine in doses of 75 to 150 mg. Codeine is more likely to cause more constipation, while Tramadol is known to cause nausea, vomiting and dizziness more often. When addressing chronic pain the symptoms of nausea and vomiting decrease with Tramadol, codeine still causes the same degree of constipation.
Tramadol vs. Meperidine
The study comparing Tramadol and Meperidine was effectuated in the situation of spinal anesthesia in cesarean section. Tramadol has proven to be more advantageous over over Meperidine in what concerns side-effects such as respiratory depression and dizziness. The ability to control post-spinal shivering in Tramadol is superior to that of Meperidine but it also causes more frequent symptoms of nausea, vomiting and drowsiness.
Tramadol vs. Morphine
When using Tramadol a set of symptoms characteristic for opioids such as drowsiness, dizziness, nausea, constipation and other is likely to be observed. Nevertheless, Tramadol induces far less respiratory depression if compared to Morphine. Tramadol is also not associated with histamine release like Morphine. In small doses, Tramadol does not affect heart rate, left-ventricular function or cardiac index. Although, orthostatic changes in blood pressure have been reported.
Tramadol vs. Codeine combinations
Tramadol maximum painkiller effectiveness for overcoming severe pain after oral surgical procedures is reported to be similar to that of 60 milligrams of codeine. However, a special nonsteroidal anti-inflammatory drug that represents an aspirin/codeine or acetaminophen/codeine combination is more effective than Tramadol.
Tramadol vs. Diclofenac
Tramadol possesses the same analgesic effects as Diclofenac in post tonsillectomy pain symptoms, which can be used for substituting nonsteroidal anti-inflammatory drug that can deliver adverse effects.
Comparison with NSAIDs
Comparative studies have displayed that Tramadol provides better analgesic effects compared to Ketorolac in patients subjected to day care gynecological laparoscopic procedures. In this case the analgesic effects of ketorolac are inadequate. Tramadol is generally better tolerated and has stronger analgesic properties, however it delivers more frequent side-effects like vomiting and nausea.
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